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Calcific aortic valve disease is the pathological remodeling of valve leaflets. The initial steps in valve leaflet osteogenic reprogramming are not fully understood. As TERT (telomerase reverse ...

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Division of Cardiology, Department of Internal Medicine (E.J.H., M.A.F.), University of Texas Southwestern Medical Center, Dallas. Parkland Health and Hospital System ...

Endothelial dysfunction and inflammation have been implicated in the pathophysiology of cerebral small vessel disease (SVD). However, whether they are causal, and if so which components of the ...

Polyamines have been suggested to play pivotal roles in ischemic stroke and neurodegenerative disorders, but the associations of plasma polyamines with poststroke cognitive impairment (PSCI) remain ...

Identification of admission imaging biomarkers is critical to detect patients who will not respond to acute anticoagulation alone. The study aims to characterize and assess the distinct impact of ...

The association between systolic blood pressure and all-cause mortality differs between frail and nonfrail individuals, highlighting uncertainties about the effectiveness of antihypertensive ...

View all available purchase options and get full access to this article. Agarwal R, Ruilope LM, Ruiz-Hurtado G, Haller H, Schmieder RE, Anker SD, Filippatos G, Pitt B, Rossing P, Lambelet M, et al.